Using toe amputation ("declawing") of cats to test the efficacy of pain medications.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5259973/pdf/12917_2017_Article_943.pdfQuote from City The Kitty
These unethical humans used some of their cats that were purpose-bred laboratory cats from their colony and amputated the toes and claws on ONE paw, then did a washout/crossover, and 2 weeks later amputated the toes and claws on the cat’s other paw. Whatever treatment they got (Simbadol or nothing) the first time, they got the opposite the second.
These horrible human beings didn't just use a force plate analysis, they made the cats JUMP DOWN onto the force plate to measure how much weight they put on which paw. They concluded that (1) drugs good.
I quoted City, because I can't bring myself to read the paper. I think it might make me..I don't know lose my mind with fury.