Author Topic: Canine hip dysplasia genes identified  (Read 929 times)

0 Members and 1 Guest are viewing this topic.

Offline DeeDee

  • P-F's Twitter-er
  • Charter Member
  • Motor Mouth
  • Join Date: Jul 2012
  • Posts: 6013
  • Country: us
  • Barkly & Vlad
Canine hip dysplasia genes identified
« on: March 10, 2018, 12:35:22 PM »
Quote
TiHo scientists unravel genes responsible for canine hip dysplasia.

Canine hip dysplasia (CHD) plays a central role in the selection of breeding animals ever since modern dog breeding began. This inherited condition is common in all dog breeds as well as in mongrels. Researchers at the Institute for Animal Breeding and Genetics at the University of Veterinary Medicine Hannover Foundation (TiHo), has identified important genetic variants and their interrelated pathways for the pathogenesis of CHD in German Shepherds. The scientists genotyped more than 1000 German Shepherds and screened a large number of single nucleotide polymorphisms (SNPs) for their association with CHD. Professor Dr. Ottmar Distl and his doctoral student Lena Fels have published their research results in the international online journal PLOS ONE (http://dx.plos.org/10.1371/journal.pone.0096618).

CHD is caused by a malformation and instability of the hip joints. The first attempts to breed against CHD started at the end of the 1960s due to the severity of this disease and its general significance for the health of dogs. The sole basis of the breeding programs was X-rays of both hip joints. Dogs with significant and severe changes were excluded from breeding. Systematic preventative programs have been established by most dog breeding associations and have become an integral part of the selection programs in purebred dog breeding.

The genetic mechanisms responsible for CHD involve the formation of cartilage and bone. The metabolic pathways show significant similarities with osteoarthritis and chondrodysplasia in humans. “Research of CHD is of fundamental importance in terms of understanding the processes that can lead to osteoarthritis in humans”, says Distl, head of the Institute for Animal Breeding and Genetics at TiHo.

Yes. It's breed specific for German Shepherds, but it's a start now that they know what they're looking for in the genes.

The rest at: https://idw-online.de/de/news586117
« Last Edit: March 10, 2018, 12:45:30 PM by DeeDee »
"In order to really enjoy a dog, one doesn't merely try to train him to be semihuman. The point of it is to open oneself to the possibility of becoming partly a dog." Edward Hoagland
"Thorns may hurt you, men desert you, sunlight turn to fog; but you're never friendless ever, if you have a dog."

Tags: